姓名：杨纪春
职称：特聘研究员
专业：化学
所属二级学科：分析化学
研究方向：药物递送与疾病精准诊疗
E-mail: yangjichun@mail.neu.edu.cn
个人简历：
近年来的主要研究工作：
面向人民生命健康，以医工融合为切入点，聚焦于仿生纳米药物载体的研发，长期围绕临床上肿瘤治疗所面临的耐药性抵抗、治疗毒副作用大、治疗后易转移复发三大瓶颈问题开展产学研一体化研究工作，先后主持国家自然科学基金面上项目、青年项目、国家重点研发子课题、中国博士后面上项目、重庆市来渝人才项目等省部级以上科研项目十余项。以第一作者或通讯作者身份在ACS Nano、Chem Sci、Biomaterials等期刊发表论文30余篇，其中Nature Index及IF＞10论文17篇，获国家发明专利6项，获重庆市科技进步一等奖、中国发明协会创新创业成果奖一等奖等奖项，入选省部级人才计划巴渝学者青年学者。
近年来承担的主要项目：
1.国家自然科学基金面上项目，基于MIL-100（Fe）的双调控级联酶驱动肺癌铁死亡治疗研究,2025.01-2028.12 (项目负责人，在研)
2.国家自然科学基金青年项目，DNA 水凝胶原位固定法用于乳腺癌精准化疗并抗转移与复发的实验研究，2022.01-2025.12 (项目负责人，结题)
3.国家重点研发计划子课题，高性能免疫现场快速检测系统研发，2023.01-2026.12 (子课题负责人，在研)
4.重庆市自然科学基金面上项目，基于青蒿外泌体的免疫浸润增强型肺癌疫苗研究，2025.01-2027.12 （项目负责人，在研）
5.重庆市自然科学基金面上项目，免疫增强型靶向二氧化锰用于乳腺癌放化增敏治疗的应用研究，2022.01-2024.12 (项目负责人，结题)
近年来发表的代表性论文：
[1] Q Q Wu#, X H Chen, S T Wang, X Wang, Z X Cha, H Y Chen, Y G Ren, Y Luo, X Cui, Y Zhao, Y F Zhang, Y C Li, Z Y Ge, Sergio Benardini, Z Z Wang*, J C Yang*, Y Luo*, Biomaterials, 2026, 328, 123868. (中科院1区，IF: 12.9)
[2] X Z Xu#, H Zhou1, Y J Wan#, J Fu#, J Q Gong, R X Hong, J Tang, Q Z Wang, Y Li, K F Huang, Y Z Zhong, J C Yang*, Y Luo*, F Li*, Ultrasound-activated in situ nano-vaccines (SATNAV) for precise CRPC sono-immunotherapy via multi-reprograming the immunosuppressive microenvironment, Chemical Engineering Journal, 2026, 535, 175754. (中科院1区，IF: 13.2)
[3] J C Yang#*, Y H Wang#, K Wang#, X H Chen, Y L Liu, Q Q Wu, H Y Chen, G C Qing, Y Q Fu, X Cui, Y Luo, S T Wang, G L Duan, M Y Zhang, Y M Jia, X H Hu, Z Z Wang, X J Liang*, H P Xu*, Y Luo*, A spatiotemporally controllable DNA hydrogel mesh for focused anti-metastasis therapy of cancer, ACS Nano, 2025, 19: 31183-31200. (Supplementary Cover, Nature Index, 中科院1区，IF: 16.0)
[4] J C Yang#*, Q Q Wu#, Y Q Fu#, X H Chen, H Y Chen, Y H Wang, X Wu, X Cui, S T Wang, Y Luo, Y F Zhang, Y C Li, Y Zhao, Z X Cha, L K Shi, X L Jiao*, F Li*, Y Luo*, Turmeric extracellular vesicles-derived “all-in-one” nanoagent enables full-cycle synergistic immunomodulation of lung cancer, Bioactive Materials, 2026. 56, 666-681. (中科院1区，IF: 20.3)
[5] X H Chen#, H X Liu#, N Y Ma#, C Y Sun, Y C Li, H Y Chen, Q Q Wu, Z Z Wang, J C Yang*, G X Liu*, Y Luo*, Precise determination of CpG methylation through entropy-driven cascade circuit, Analytical Chemistry, 2025, 97: 13325-13334. (Supplementary Cover, Nature Index, 中科院1区，IF: 6.7)
[6] J C Yang#*, C Y Sun#, Y F Zhang#, J N Ji, Y H Wang, Q Q Wu, Y Zhao, Z X Cha, Y C Li, X Cui, Y Luo, S T Wang, Z Z Wang, Sergio Benardini, X H Chen*, Luo Y*, Endogenous stimuli-derived self-assembled DNA tetrahedron (MESH) for precise imaging and activatable mitochondrial interference therapy, Chemical Engineering Journal, 2025, 524, 169613. (中科院1区，IF: 13.2)
[7] Z H Li, Z H Cai, Y H Wang, Y L Liu, G F Li, X Yang, M Deng, Y C Chen, J C Yang*, Y Luo*, Gong C Y*, Zhu T*, Laser-emission vibrational microscopy of microdroplet arrays for high-throughput screening of hyperipidemia, Light: Science & Applications, 2025, 327. (中科院1区，IF: 23.4)
[8] J C Yang#*, Y H Wang#, Y Q Fu#, S T Wang, Y Luo, X Cui, C Y Sun, J N Ji, J X Mo , Y Wang, Y L Liu, X H Hu, X H Chen, Y M Jia*, Y Luo*, Plant extracellular vesicles: A promising bionic medicine platform for disease treatment and drug delivery. Interdisciplinary Medicine, 2025: e20240101. (中科院1区，IF: 13.6)
[9]Y Chen#, H Y Chen#, X H Chen#, Y F Zhang, W Tu, J X Mo, S S Tian, C Y Sun, X Q Meng, Z Z Wang*, J C Yang*, Y Luo*. Precision detection of hepatocellular carcinoma-associated telomeraseRNA with SA@Comb-HCR nanosystem, Biosens Bioelectron, 2024, 261: 116496. (中科院1区，IF: 10.7)
[10] J C Yang#*, C Zhang#, X H Chen#, D J Zhou, Z X Sun, R Y Niu, Y Zhu, H Y Chen, L Wang, Y Chen, Y H Wang, Y Q Fu, N Y Ma, J J Li*, Y Luo*. Ultra-efficient radio-immunotherapy for reprogramming the hypoxic and immunosuppressive tumor microenvironment with durable innate immune memory, Biomaterials, 2023, 302: 122303. (中科院1区，IF: 14.0)
[11] L Wang#, K Wang#, X H Wang#, Niu R Y, X H Chen, Y Zhu, Z X Sun, J C Yang*, G X Liu*, Y Luo*. Intelligent dual-lock deoxyribonucleic acid automatons boosting precise tumor Imaging, ACS Applied Materials & Interfaces, 2023, 15(3): 3826-3838. (中科院1区，IF: 10.5)
[12] X H Chen#, Y Deng#, R Y Niu, Z X Sun, Alya Batool, L Wang, C Zhang, N Y Ma, Q T Yang, G X Liu*, J C Yang*, Y Luo*. Cancer-derived small extracellular vesicles PICKER, Analytical Chemistry, 2022, 94(38): 13019-13027. (Front Cover, Nature Index, 中科院1区，IF: 8.008)
[13] J C Yang, S J Pan, S Q Gao, T Y Li, H P Xu*, CO/chemosensitization/ antiangiogenesis synergistic therapy with H2O2-responsive diselenide-containing polymer, Biomaterials, 2021, 271: 120721. (中科院1区，IF: 15.304)
[14] J C Yang, S J Pan, S Q Gao, Y H Dai, H P Xu*, Anti-recurrence/metastasis and chemosensitization therapy with thioredoxin reductase-interfering drug delivery system, Biomaterials, 2020, 249, 120054. (中科院1区，IF: 12.479)
[15] J C Yang, Y Shang, Y H Li, Y Cui, X B Yin*, An “all-in-one” antitumor and anti-recurrence/metastasis nanomedicine with multi-drug co-loading and burst drug release for multi-modality therapy, Chemical Science, 2018, 9: 7210-7217. (Nature Index, 中科院1区，IF: 9.556)
